Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders.
نویسندگان
چکیده
Gregory A. Light and Risto Näätänen Mental Illness, Research, Education and Clinical Center, Veteran’s Affairs San Diego Healthcare System; Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093-0804; Center of Functionally Integrative Neuroscience, University of Århus, Århus, Denmark; Department of Psychology, University of Tartu, Tartu, Estonia; and Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland
منابع مشابه
Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis
BACKGROUND Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinic...
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Mismatch negativity (MMN) is a robustly abnormal brainwave in chronically ill schizophrenia that has generated interest as a disease presence biomarker. Reports of MMN reduction in first-episode schizophrenia have been equivocal, raising uncertainty about its reduction at first psychotic break. Here we tested 29 schizophrenia-spectrum participants under 1 year from their first hospitalization f...
متن کاملIncreased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations.
OBJECTIVE Schizophrenia is associated with aberrant event-related potentials (ERPs) such as reductions in P300, processing negativity and mismatch negativity amplitudes. These deficits may be related to the propensity of schizophrenia patients to experience auditory verbal hallucinations (AVH). However, AVH are part of extensive and variable symptomatology in schizophrenia. For this reason non-...
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Recent reviews and meta-analyses suggest that reducing the duration of untreated psychosis leads to better symptomatic and functional outcome in patients with psychotic disorder. Early intervention attenuates the symptoms of individuals at clinical high-risk (HR) for psychosis and may delay or prevent their transition to psychosis. Identifying biological markers in the early stages of psychotic...
متن کاملFuture clinical uses of neurophysiological biomarkers to predict and monitor treatment response for schizophrenia.
Advances in psychiatric neuroscience have transformed our understanding of impaired and spared brain functions in psychotic illnesses. Despite substantial progress, few (if any) laboratory tests have graduated to clinics to inform diagnoses, guide treatments, and monitor treatment response. Providers must rely on careful behavioral observation and interview techniques to make inferences about p...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 110 38 شماره
صفحات -
تاریخ انتشار 2013